Molecular pathology of thyroid cancer: diagnostic and clinical implications

Consensus Molecular Subtypes of Colorectal Cancer and their Clinical Implications

The colorectal cancer (CRC) subtyping consortium has unified six independent molecular classification systems, based on gene expression data, into a single consensus system with four distinct groups, known as the consensus molecular subtypes (CMS); clinical implications are discussed in this review based on articles relevant to the CMS of CRC indexed in PubMed as well as the authors’ own ...

17. Diagnostic Molecular Markers in Thyroid Cancer

Thyroid cancer is the commonest classical endocrine tumor, accounting for approximately 1% of all cancers. The diagnosis of thyroid cancer is typically made on cytopathologic features on fine needle aspiration or histological features on surgical samples. Following treatment of patients with thyroidectomy, and in some cases radioiodine, patients are monitored for disease recurrence using a vari...

Diagnostic molecular pathology: current techniques and clinical applications, part I.

Evaluation of molecular diagnostic approaches for the detection of BRAF p.V600E mutations in papillary thyroid cancer: Clinical implications

Differentiated papillary thyroid cancer (PTC) is the most common cancer of the endocrine system. PTC has a very good prognosis and a high 5 year survival rate; however, some patients are unresponsive to treatment, and their diagnosis eventually results in death. Recent efforts have focused on searching for prognostic and predictive factors that may enable treatment personalization and monitorin...

I-17: Failed Fertilization: from Molecular,Diagnostic and Clinical Perspectives

Low and/or total failed fertilization following ICSI is a disappointing effect that some couples may face during their treatment which may have severe social and economic consequences for these infertile couples. This phenomenon has been mainly attributed to failed oocyte activation post ICSI. Researchers have regarded this failure due to the absence or deficiency of sperm associated to oocyte ...